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Document type:
journal article 
Author(s):
Gröschel, Stefan; Bommer, Martin; Hutter, Barbara; Budczies, Jan; Bonekamp, David; Heining, Christoph; Horak, Peter; Fröhlich, Martina; Uhrig, Sebastian; Hübschmann, Daniel; Geörg, Christina; Richter, Daniela; Pfarr, Nicole; Pfütze, Katrin; Wolf, Stephan; Schirmacher, Peter; Jäger, Dirk; von Kalle, Christof; Brors, Benedikt; Glimm, Hanno; Weichert, Wilko; Stenzinger, Albrecht; Fröhling, Stefan 
Title:
Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification. 
Abstract:
Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profiling has the potential to contribute to diagnostic categorization and, most importantly, guide CUP therapy through identification of actionable lesions. We here report the case of an advanced-stage ma...    »
 
Journal title abbreviation:
Cold Spring Harb Mol Case Stud 
Year:
2016 
Journal volume:
Journal issue:
Pages contribution:
a001180 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2373-2865 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie