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Document type:
journal article 
Author(s):
Saalfrank, A; Janssen, K-P; Ravon, M; Flisikowski, K; Eser, S; Steiger, K; Flisikowska, T; Müller-Fliedner, P; Schulze, É; Brönner, C; Gnann, A; Kappe, E; Böhm, B; Schade, B; Certa, U; Saur, D; Esposito, I; Kind, A; Schnieke, A 
Title:
A porcine model of osteosarcoma. 
Abstract:
We previously produced pigs with a latent oncogenic TP53 mutation. Humans with TP53 germline mutations are predisposed to a wide spectrum of early-onset cancers, predominantly breast, brain, adrenal gland cancer, soft tissue sarcomas and osteosarcomas. Loss of p53 function has been observed in>50% of human cancers. Here we demonstrate that porcine mesenchymal stem cells (MSCs) convert to a transformed phenotype after activation of latent oncogenic TP53(R167H) and KRAS(G12D), and overexpression o...    »
 
Journal title abbreviation:
Oncogenesis 
Year:
2016 
Journal volume:
Pages contribution:
e210 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Chirurgiesche Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie