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Dokumenttyp:
journal article 
Autor(en):
Russell, Ronan; Perkhofer, Lukas; Liebau, Stefan; Lin, Qiong; Lechel, André; Feld, Fenja M; Hessmann, Elisabeth; Gaedcke, Jochen; Güthle, Melanie; Zenke, Martin; Hartmann, Daniel; von Figura, Guido; Weissinger, Stephanie E; Rudolph, Karl-Lenhard; Möller, Peter; Lennerz, Jochen K; Seufferlein, Thomas; Wagner, Martin; Kleger, Alexander 
Titel:
Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC induces a greater number of proliferative precursor lesions coupled with a pronounced fibrotic reaction. ATM-targeted mice display altered TGF?-superfamily signalling and enhanced epithelial-to-mesenchyma...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2015 
Band / Volume:
Seitenangaben Beitrag:
7677 
Sprache:
eng 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik