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Dokumenttyp:
journal article 
Autor(en):
Kong, Bo; Cheng, Tao; Qian, Chengjia; Wu, Weiwei; Steiger, Katja; Cao, Jing; Schlitter, Anna Melissa; Regel, Ivonne; Raulefs, Susanne; Friess, Helmut; Erkan, Mert; Esposito, Irene; Kleeff, Jörg; Michalski, Christoph W 
Titel:
Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma. 
Abstract:
Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyzing whether activation of mTOR with a concomitant loss of p53 may initiate ACC.We generated transgenic mouse models in which mTOR was hyperactivated through pancreas-specific, homozygous tube...    »
 
Zeitschriftentitel:
Mol Cancer 
Jahr:
2015 
Band / Volume:
14 
Seitenangaben Beitrag:
212 
Sprache:
eng 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie