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Dokumenttyp:
journal article 
Autor(en):
Sainz, Bruno; Alcala, Sonia; Garcia, Elena; Sanchez-Ripoll, Yolanda; Azevedo, Maria M; Cioffi, Michele; Tatari, Marianthi; Miranda-Lorenzo, Irene; Hidalgo, Manuel; Gomez-Lopez, Gonzalo; Cañamero, Marta; Erkan, Mert; Kleeff, Jörg; García-Silva, Susana; Sancho, Patricia; Hermann, Patrick C; Heeschen, Christopher 
Titel:
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment. 
Abstract:
The tumour stroma/microenvironment not only provides structural support for tumour development, but more importantly it provides cues to cancer stem cells (CSCs) that regulate their self-renewal and metastatic potential. This is certainly true for pancreatic ductal adenocarcinomas (PDAC), where tumour-associated fibroblasts, pancreatic stellate cells and immune cells create an abundant paracrine niche for CSCs via microenvironment-secreted factors. Thus understanding the role that tumour stroma...    »
 
Zeitschriftentitel:
Gut 
Jahr:
2015 
Band / Volume:
64 
Heft / Issue:
12 
Seitenangaben Beitrag:
1921-35 
Sprache:
eng 
Print-ISSN:
0017-5749 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik