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Dokumenttyp:
journal article 
Autor(en):
Parsons, Christopher G; Ruitenberg, Maarten; Freitag, Christine E; Sroka-Saidi, Kamila; Russ, Hermann; Rammes, Gerhard 
Titel:
MRZ-99030 - A novel modulator of A? aggregation: I - Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD). 
Abstract:
Therapeutic approaches addressing ?-amyloid1-42 (A?1-42) aggregation represent a promising neuroprotective strategy for the treatment of Alzheimer's disease, dry age-related macular degeneration (AMD) and glaucoma. MRZ-99030 is a dipeptide containing d-tryptophan and 2-amino-2-methylpropionic acid in clinical development for the topical treatment of glaucoma and AMD. MRZ-99030 is an A? aggregation modulator, previously reported to prevent the formation of soluble toxic oligomeric A? species. The...    »
 
Zeitschriftentitel:
Neuropharmacology 
Jahr:
2015 
Band / Volume:
92 
Seitenangaben Beitrag:
158-69 
Sprache:
eng 
Print-ISSN:
0028-3908 
TUM Einrichtung:
Klinik für Anästhesiologie