User: Guest  Login
Document type:
journal article 
Author(s):
Lee, Youjin; Mitsdoerffer, Meike; Xiao, Sheng; Gu, Guangxiang; Sobel, Raymond A; Kuchroo, Vijay K 
Title:
IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. 
Abstract:
IL-17-producing CD4+ T cells (Th17 cells) have well-described pathogenic roles in tissue inflammation and autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE); however, the involvement of IL-21 in these processes has remained controversial. While IL-21 is an essential autocrine amplification factor for differentiation of Th17 cells, the loss of IL-21 or IL-21 receptor (IL-21R) does not protect mice from actively induced EAE. Here, we utilized a transgenic EAE mouse model...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2015 
Journal volume:
125 
Journal issue:
11 
Pages contribution:
4011-20 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Neurologische Klinik und Poliklinik