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Document type:
journal article 
Author(s):
Knies, Nathalie; Alankus, Begüm; Weilemann, Andre; Tzankov, Alexandar; Brunner, Kristina; Ruff, Tanja; Kremer, Marcus; Keller, Ulrich B; Lenz, Georg; Ruland, Jürgen 
Title:
Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-?B and JNK activation. 
Abstract:
The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive nuclear factor kappa-B (NF-?B) activation, which is required for tumor cell survival. BCR-induced NF-?B activation requires caspase recruitment domain-containing protein 11 (CARD11), and CARD11 gain-of-function mutations are recurrently detected in human diffuse large B-cell lymphoma (DLBCL). To investigate the consequences of dysregulated CA...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2015 
Journal volume:
112 
Journal issue:
52 
Pages contribution:
E7230-8 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; III. Medizinische Klinik und Poliklinik