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Document type:
journal article 
Author(s):
Schwoerer, Alexander P; Scheel, Hanno; Friederich, Patrick 
Title:
A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. 
Abstract:
Intoxication with local anesthetics may induce cardiac arrhythmias by interaction with ion channels. Ropivacaine has been introduced into clinical anesthesia as a safer alternative to bupivacaine, which is associated with a relatively high risk of cardiac arrhythmias. Diverging safety profiles may result from differences in the mode of interaction with cardiac Na(+) channels. We conducted this study to test this hypothesis and to provide experimental basis for the ongoing discussion regarding th...    »
 
Journal title abbreviation:
Anesth Analg 
Year:
2015 
Journal volume:
120 
Journal issue:
Pages contribution:
1226-34 
Language:
eng 
Print-ISSN:
0003-2999 
TUM Institution:
Klinik für Anästhesiologie