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Document type:
journal article 
Author(s):
Mattusch, Corinna; Kratzer, Stephan; Buerge, Martina; Kreuzer, Matthias; Engel, Tatiana; Kopp, Claudia; Biel, Martin; Hammelmann, Verena; Ying, Shui-Wang; Goldstein, Peter A; Kochs, Eberhard; Haseneder, Rainer; Rammes, Gerhard 
Title:
Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments. 
Abstract:
The thalamus is thought to be crucially involved in the anesthetic state. Here, we investigated the effect of the inhaled anesthetic xenon on stimulus-evoked thalamocortical network activity and on excitability of thalamocortical neurons. Because hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are key regulators of neuronal excitability in the thalamus, the effect of xenon on HCN channels was examined.The effects of xenon on thalamocortical network activity were invest...    »
 
Journal title abbreviation:
Anesthesiology 
Year:
2015 
Journal volume:
122 
Journal issue:
Pages contribution:
1047-59 
Language:
eng 
Print-ISSN:
0003-3022 
TUM Institution:
Klinik für Anästhesiologie