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Dokumenttyp:
journal article 
Autor(en):
Mattusch, Corinna; Kratzer, Stephan; Buerge, Martina; Kreuzer, Matthias; Engel, Tatiana; Kopp, Claudia; Biel, Martin; Hammelmann, Verena; Ying, Shui-Wang; Goldstein, Peter A; Kochs, Eberhard; Haseneder, Rainer; Rammes, Gerhard 
Titel:
Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments. 
Abstract:
The thalamus is thought to be crucially involved in the anesthetic state. Here, we investigated the effect of the inhaled anesthetic xenon on stimulus-evoked thalamocortical network activity and on excitability of thalamocortical neurons. Because hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are key regulators of neuronal excitability in the thalamus, the effect of xenon on HCN channels was examined.The effects of xenon on thalamocortical network activity were invest...    »
 
Zeitschriftentitel:
Anesthesiology 
Jahr:
2015 
Band / Volume:
122 
Heft / Issue:
Seitenangaben Beitrag:
1047-59 
Sprache:
eng 
Print-ISSN:
0003-3022 
TUM Einrichtung:
Klinik für Anästhesiologie