Improved exercise performance and quality of life after percutaneous pulmonary valve implantation.

Müller, Jan; Engelhardt, Andrea; Fratz, Sohrab; Eicken, Andreas; Ewert, Peter; Hager, Alfred

doi:10.1016/j.ijcard.2014.03.002

journal article

Document type:: Journal Article
Author(s):: Müller, Jan; Engelhardt, Andrea; Fratz, Sohrab; Eicken, Andreas; Ewert, Peter; Hager, Alfred
Title:: Improved exercise performance and quality of life after percutaneous pulmonary valve implantation.
Abstract:: Percutaneous pulmonary valve implantation (PPVI) has emerged as a new approach to treat patients with dysfunctional pulmonary valve conduits. Short- and midterm results have outlined hemodynamic improvements and increase in exercise performance. However, there is a lack of knowledge about quality of life at short term follow-up.From July 2007 to March 2013, we investigated 59 patients (17 female; median age 22.8 years) undergoing PPVI in our institution. 46 had predominant pulmonary stenosis (PS) and 13 had predominant pulmonary regurgitation (PR). They answered the quality of life questionnaire (SF-36) and underwent a cardiopulmonary exercise test and Cardiovascular Magnetic Resonance before and 6 months after PPVI.Peak oxygen uptake improved significantly from 27.2 (18.9; 34.0) ml/min/kg to 29.2 (22.4; 35.3) ml/min/kg (p<.0001), and from 69.6 (55.9; 83.6) %predicted to 76.3 (67.9; 92.7) %predicted, respectively. Improvements were seen in both, the PS (71.9 to 78.3 %predicted; p<.0001) and PR (62.7 to 73.0 %predicted; p<.0001) group. Self-estimated quality of life was good already before PPVI but increased in almost all domains 6 months after PPVI in PS and PR group. Significant improvements developed in "physical function", "general health perception" and "health transition" in both groups, and "physical role functioning", "vitality" and "mental health" only in the PS group.In patients with dysfunctional pulmonary valve conduits exercise performance and quality of life improve substantially 6months after successful percutaneous pulmonary valve implantation.
Journal title abbreviation:: Int J Cardiol
Year:: 2014
Journal volume:: 173
Journal issue:: 3
Pages contribution:: 388-92
Language:: eng
Fulltext / DOI:: doi:10.1016/j.ijcard.2014.03.002
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/24713459
Print-ISSN:: 0167-5273
TUM Institution:: Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Kinderkardiologie und angeborene Herzfehler (DHM) (Prof. Ewert)2014