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Document type:
Case Reports; Journal Article; Article 
Author(s):
Müller, K; Schlamann, A; Guckenberger, M; Warmuth-Metz, M; Glück, A; Pietschmann, S; Wawer, A; Kortmann, R-D; Kramm, C; von Bueren, A O 
Title:
Craniospinal irradiation with concurrent temozolomide for primary metastatic pediatric high-grade or diffuse intrinsic pontine gliomas. A first report from the GPOH-HIT-HGG Study Group. 
Abstract:
High-grade (HGG) and diffuse intrinsic pontine gliomas (DIPG) with primary metastatic spread are extremely rare and have a dismal prognosis. Analogous to simultaneous radiochemotherapy in non-metastatic HGG and DIPG, concurrent craniospinal irradiation (CSI) and metronomic temozolomide (metroTMZ) may represent a reasonable therapeutic approach. However, the antitumor efficacy and toxicity of this treatment still have to be investigated.Between March 2007 and December 2012, six children with prim...    »
 
Journal title abbreviation:
Strahlenther Onkol 
Year:
2014 
Journal volume:
190 
Journal issue:
Pages contribution:
377-81 
Language:
eng 
Print-ISSN:
0179-7158 
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin