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Document type:
journal article 
Author(s):
Pickhard, Anja; Siegl, Michael; Baumann, Alexander; Huhn, Maximilian; Wirth, Markus; Reiter, Rudolf; Rudelius, Martina; Piontek, Guido; Brockhoff, Gero 
Title:
The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism. 
Abstract:
The aim of this study was to evaluate the efficiency of cetuximab-based anti-EGFR treatment and Aurora kinase A / B knockdown as a function of Aurora kinase polymorphism in HNSCC cell lines.First, protein expression of Aurora kinase A / B and EGFR and Aurora kinase A polymorphism were studied in tumour samples. The survival and proliferation of Aurora kinase A homo- (Cal27) and heterozygous (HN) HNSCC cell lines was evaluated using a colony formation assay and a flow cytometric assay. Also, aneu...    »
 
Journal title abbreviation:
Oncotarget 
Year:
2014 
Journal volume:
Journal issue:
14 
Pages contribution:
5428-38 
Language:
eng 
TUM Institution:
Hals-, Nasen-, Ohrenklinik und Poliklinik