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Dokumenttyp:
journal article 
Autor(en):
Schiefler, Carlotta; Piontek, Guido; Doescher, Johannes; Schuettler, Dominik; Mißlbeck, Martin; Rudelius, Martina; Haug, Anna; Reiter, Rudolf; Brockhoff, Gero; Pickhard, Anja 
Titel:
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk. 
Abstract:
SphK1 is known to play a role in tumor progression, resistance to radiochemotherapy, and migration patterns. As the overall survival rates of squamous cell carcinoma of the head and neck (HNSCC) remain poor due to limitations in surgery and irradiation and chemotherapy resistance, SphK1 is an important enzyme to investigate. The purpose of this study was to elucidate the impact of SphK1 on irradiation efficacy of HNSCC in-vitro with emphasis on EGFR signaling. By immunhistochemical staining we f...    »
 
Zeitschriftentitel:
Oncotarget 
Jahr:
2014 
Band / Volume:
Heft / Issue:
20 
Seitenangaben Beitrag:
9877-88 
Sprache:
eng 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik