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Document type:
journal article 
Author(s):
Butinar, M; Prebanda, M T; Rajkovi?, J; Jeri?, B; Stoka, V; Peters, C; Reinheckel, T; Krüger, A; Turk, V; Turk, B; Vasiljeva, O 
Title:
Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model. 
Abstract:
Lysosomal cysteine cathepsins contribute to proteolytic events promoting tumor growth and metastasis. Their enzymatic activity, however, is tightly regulated by endogenous inhibitors. To investigate the role of cathepsin inhibitor stefin B (Stfb) in mammary cancer, Stfb null mice were crossed with transgenic polyoma virus middle T oncogene (PyMT) breast cancer mice. We show that ablation of Stfb resulted in reduced size of mammary tumors but did not affect their rate of metastasis. Importantly,...    »
 
Journal title abbreviation:
Oncogene 
Year:
2014 
Journal volume:
33 
Journal issue:
26 
Pages contribution:
3392-400 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung