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Document type:
journal article 
Author(s):
Kratzer, Stephan; Irl, Hedwig; Mattusch, Corinna; Bürge, Martina; Kurz, Jörg; Kochs, Eberhard; Eder, Matthias; Rammes, Gerhard; Haseneder, Rainer 
Title:
Tranexamic acid impairs ?-aminobutyric acid receptor type A-mediated synaptic transmission in the murine amygdala: a potential mechanism for drug-induced seizures? 
Abstract:
Tranexamic acid (TXA) is commonly used to reduce blood loss in cardiac surgery and in trauma patients. High-dose application of TXA is associated with an increased risk of postoperative seizures. The neuronal mechanisms underlying this proconvulsant action of TXA are not fully understood. In this study, the authors investigated the effects of TXA on neuronal excitability and synaptic transmission in the basolateral amygdala.Patch clamp recordings and voltage-sensitive dye imaging were performed...    »
 
Journal title abbreviation:
Anesthesiology 
Year:
2014 
Journal volume:
120 
Journal issue:
Pages contribution:
639-49 
Language:
eng 
Print-ISSN:
0003-3022 
TUM Institution:
Klinik für Anästhesiologie; Abteilung für Kardioanästhesiologie