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Document type:
journal article 
Author(s):
Bot, Ilze; Daissormont, Isabelle T M N; Zernecke, Alma; van Puijvelde, Gijs H M; Kramp, Birgit; de Jager, Saskia C A; Sluimer, Judith C; Manca, Marco; Hérias, Veronica; Westra, Marijke M; Bot, Martine; van Santbrink, Peter J; van Berkel, Theo J C; Su, Lishan; Skjelland, Mona; Gullestad, Lars; Kuiper, Johan; Halvorsen, Bente; Aukrust, Paul; Koenen, Rory R; Weber, Christian; Biessen, Erik A L 
Title:
CXCR4 blockade induces atherosclerosis by affecting neutrophil function. 
Abstract:
The SDF-1?/CXCR4 dyad was previously shown by us and others to be instrumental in intimal hyperplasia as well as early stage atherosclerosis. We here sought to investigate its impact on clinically relevant stages of atherosclerosis in mouse and man.Immunohistochemical analysis of CXCR4 expression in human atherosclerotic lesions revealed a progressive accumulation of CXCR4(+) cells during plaque progression. To address causal involvement of CXCR4 in advanced stages of atherosclerosis we reconsti...    »
 
Journal title abbreviation:
J Mol Cell Cardiol 
Year:
2014 
Journal volume:
74 
Pages contribution:
44-52 
Language:
eng 
Print-ISSN:
0022-2828 
TUM Institution:
Klinik für Gefäßchirurgie