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Document type:
journal article 
Author(s):
Westmeyer, Gil G; Emer, Yelena; Lintelmann, Jutta; Jasanoff, Alan 
Title:
MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch. 
Abstract:
The ability to map patterns of gene expression noninvasively in living animals could have impact in many areas of biology. Reporter systems compatible with MRI could be particularly valuable, but existing strategies tend to lack sensitivity or specificity. Here we address the challenge of MRI-based gene mapping using the reporter enzyme secreted alkaline phosphatase (SEAP), in conjunction with a water-soluble metalloporphyrin contrast agent. SEAP cleaves the porphyrin into an insoluble product t...    »
 
Journal title abbreviation:
Chem Biol 
Year:
2014 
Journal volume:
21 
Journal issue:
Pages contribution:
422-9 
Language:
eng 
Print-ISSN:
1074-5521 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik