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Document type:
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Article 
Author(s):
Schlenk, Richard F; Kayser, Sabine; Bullinger, Lars; Kobbe, Guido; Casper, Jochen; Ringhoffer, Mark; Held, Gerhard; Brossart, Peter; Lübbert, Michael; Salih, Helmut R; Kindler, Thomas; Horst, Heinz A; Wulf, Gerald; Nachbaur, David; Götze, Katharina; Lamparter, Alexander; Paschka, Peter; Gaidzik, Verena I; Teleanu, Veronica; Späth, Daniela; Benner, Axel; Krauter, Jürgen; Ganser, Arnold; Döhner, Hartmut; Döhner, Konstanze 
Title:
Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation. 
Abstract:
The objective was to evaluate the prognostic and predictive impact of allelic ratio and insertion site (IS) of internal tandem duplications (ITDs), as well as concurrent gene mutations, with regard to postremission therapy in 323 patients with FLT3-ITD-positive acute myeloid leukemia (AML). Increasing FLT3-ITD allelic ratio (P = .004) and IS in the tyrosine kinase domain 1 (TKD1, P = .06) were associated with low complete remission (CR) rates. After postremission therapy including intensive chem...    »
 
Journal title abbreviation:
Blood 
Year:
2014 
Journal volume:
124 
Journal issue:
23 
Pages contribution:
3441-9 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)