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Document type:
journal article 
Author(s):
Tsaousidou, Eva; Paeger, Lars; Belgardt, Bengt F; Pal, Martin; Wunderlich, Claudia M; Brönneke, Hella; Collienne, Ursel; Hampel, Brigitte; Wunderlich, F Thomas; Schmidt-Supprian, Marc; Kloppenburg, Peter; Brüning, Jens C 
Title:
Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. 
Abstract:
Activation of c-Jun N-terminal kinase 1 (JNK1)- and inhibitor of nuclear factor kappa-B kinase 2 (IKK2)-dependent signaling plays a crucial role in the development of obesity-associated insulin and leptin resistance not only in peripheral tissues but also in the CNS. Here, we demonstrate that constitutive JNK activation in agouti-related peptide (AgRP)-expressing neurons of the hypothalamus is sufficient to induce weight gain and adiposity in mice as a consequence of hyperphagia. JNK activation...    »
 
Journal title abbreviation:
Cell Rep 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
1495-506 
Language:
eng 
TUM Institution:
III. Medizinische Klinik und Poliklinik