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Document type:
journal article 
Author(s):
Peschke, Katrin; Weitzmann, Anke; Heger, Klaus; Behrendt, Rayk; Schubert, Nadja; Scholten, Julia; Voehringer, David; Hartmann, Karin; Dudeck, Anne; Schmidt-Supprian, Marc; Roers, Axel 
Title:
I?B kinase 2 is essential for IgE-induced mast cell de novo cytokine production but not for degranulation. 
Abstract:
The immunoglobulin E (IgE)-mediated mast cell (MC) response is central to the pathogenesis of type I allergy and asthma. I?B kinase 2 (IKK2) was reported to couple IgE-induced signals to MC degranulation by phosphorylating the SNARE protein SNAP23. We investigated MC responses in mice with MC-specific inactivation of IKK2 or NF-?B essential modulator (NEMO), or animals with MC-specific expression of a mutant, constitutively active IKK2. We show that the IgE-induced late-phase cytokine response i...    »
 
Journal title abbreviation:
Cell Rep 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
1300-7 
Language:
eng 
TUM Institution:
III. Medizinische Klinik und Poliklinik