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Document type:
journal article 
Author(s):
Unland, Rebekka; Kerl, Kornelius; Schlosser, Sabrina; Farwick, Nicole; Plagemann, Tanja; Lechtape, Birigit; Clifford, Steven C; Kreth, Jonas H; Gerss, Joachim; Mühlisch, Jörg; Richter, Günther H S; Hasselblatt, Martin; Frühwald, Michael C 
Title:
Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system. 
Abstract:
Epigenetic alterations are common events in cancer. Using a genome wide methylation screen (Restriction Landmark Genomic Scanning-RLGS) we identified the gene for the dopamine receptor D4 (DRD4) as tumor-specific methylated. As DRD4 is involved in early brain development and may thus be involved in developmentally dependent tumors of the CNS in children epigenetic deregulation of DRD4 and its functional consequences were analyzed in vitro. CpG methylation of DRD4 was detected in 18/24 medullobla...    »
 
Journal title abbreviation:
J Neurooncol 
Year:
2014 
Journal volume:
116 
Journal issue:
Pages contribution:
237-49 
Language:
eng 
Print-ISSN:
0167-594X 
TUM Institution:
Kinderklinik und Poliklinik