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Dokumenttyp:
journal article 
Autor(en):
Hinkel, Rabea; Trenkwalder, Teresa; Petersen, Björn; Husada, Wira; Gesenhues, Florian; Lee, Seungmin; Hannappel, Ewald; Bock-Marquette, Ildiko; Theisen, Daniel; Leitner, Laura; Boekstegers, Peter; Cierniewski, Czeslaw; Müller, Oliver J; le Noble, Ferdinand; Adams, Ralf H; Weinl, Christine; Nordheim, Alfred; Reichart, Bruno; Weber, Christian; Olson, Eric; Posern, Guido; Deindl, Elisabeth; Niemann, Heiner; Kupatt, Christian 
Titel:
MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. 
Abstract:
Gradual occlusion of coronary arteries may result in reversible loss of cardiomyocyte function (hibernating myocardium), which is amenable to therapeutic neovascularization. The role of myocardin-related transcription factors (MRTFs) co-activating serum response factor (SRF) in this process is largely unknown. Here we show that forced MRTF-A expression induces CCN1 and CCN2 to promote capillary proliferation and pericyte recruitment, respectively. We demonstrate that, upon G-actin binding, thymo...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2014 
Band / Volume:
Seitenangaben Beitrag:
3970 
Sprache:
eng 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik