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Dokumenttyp:
journal article 
Autor(en):
Loewe, Axel; Lutz, Yannick; Wilhelms, Mathias; Sinnecker, Daniel; Barthel, Petra; Scholz, EberhardP; Dossel, Olaf; Schmidt, Georg; Seemann, Gunnar 
Titel:
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology. 
Abstract:
AIMS: The clinical efficacy in preventing the recurrence of atrial fibrillation (AF) is higher for amiodarone than for dronedarone. Moreover, pharmacotherapy with these drugs is less successful in patients with remodelled substrate induced by chronic AF (cAF) and patients suffering from familial AF. To date, the reasons for these phenomena are only incompletely understood. We analyse the effects of the drugs in a computational model of atrial electrophysiology. METHODS AND RESULTS: The Courteman...    »
 
Zeitschriftentitel:
Europace : European pacing, arrhythmias, and cardiac electrophysiology : 
Jahr:
2014 
Band / Volume:
16 Suppl 4 
Seitenangaben Beitrag:
iv30-iv38 
Sprache:
eng 
Print-ISSN:
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik