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Dokumenttyp:
journal article 
Autor(en):
Turqueti-Neves, Adriana; Otte, Manuel; Prazeres da Costa, Olivia; Höpken, Uta E; Lipp, Martin; Buch, Thorsten; Voehringer, David 
Titel:
B-cell-intrinsic STAT6 signaling controls germinal center formation. 
Abstract:
Infection with helminths and exposure to antigens induce a strong type 2 immune response resulting in the secretion of the cytokines IL-4 and IL-13 by CD4(+) T cells and several innate cell types. IL-4 and IL-13 promote class switch recombination to IgG1 and IgE while their role for germinal center (GC) formation is poorly understood. We found a dramatic reduction in the numbers of GC B cells when investigating different type 2 immune responses in IL-4/IL-13-deficient mice. IL-4/IL-13 from T cel...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2014 
Band / Volume:
44 
Heft / Issue:
Seitenangaben Beitrag:
2130-8 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene