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Dokumenttyp:
journal article 
Autor(en):
Sharif, Omar; Gawish, Riem; Warszawska, Joanna M; Martins, Rui; Lakovits, Karin; Hladik, Anastasiya; Doninger, Bianca; Brunner, Julia; Korosec, Ana; Schwarzenbacher, Roland E; Berg, Tiina; Kralovics, Robert; Colinge, Jacques; Mesteri, Ildiko; Gilfillan, Susan; Salmaggi, Andrea; Verschoor, Admar; Colonna, Marco; Knapp, Sylvia 
Titel:
The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. 
Abstract:
Phagocytosis and inflammation within the lungs is crucial for host defense during bacterial pneumonia. Triggering receptor expressed on myeloid cells (TREM)-2 was proposed to negatively regulate TLR-mediated responses and enhance phagocytosis by macrophages, but the role of TREM-2 in respiratory tract infections is unknown. Here, we established the presence of TREM-2 on alveolar macrophages (AM) and explored the function of TREM-2 in the innate immune response to pneumococcal infection in vivo....    »
 
Zeitschriftentitel:
PLoS Pathog 
Jahr:
2014 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
e1004167 
Sprache:
eng 
Print-ISSN:
1553-7366 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene