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Document type:
journal article 
Author(s):
Doppler, Stefanie A; Werner, Astrid; Barz, Melanie; Lahm, Harald; Deutsch, Marcus-André; Dreßen, Martina; Schiemann, Matthias; Voss, Bernhard; Gregoire, Serge; Kuppusamy, Rajarajan; Wu, Sean M; Lange, Rüdiger; Krane, Markus 
Title:
Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer. 
Abstract:
Vertebrate heart development is strictly regulated by temporal and spatial expression of growth and transcription factors (TFs). We analyzed nine TFs, selected by in silico analysis of an Nkx2.5 enhancer, for their ability to transactivate the respective enhancer element that drives, specifically, expression of genes in cardiac progenitor cells (CPCs). Mzf1 showed significant activity in reporter assays and bound directly to the Nkx2.5 cardiac enhancer (Nkx2.5 CE) during murine ES cell different...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2014 
Journal volume:
Journal issue:
12 
Pages contribution:
e113775 
Language:
eng 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene