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Dokumenttyp:
journal article 
Autor(en):
Fernandes-Rosa, Fabio Luiz; Williams, Tracy Ann; Riester, Anna; Steichen, Olivier; Beuschlein, Felix; Boulkroun, Sheerazed; Strom, Tim M; Monticone, Silvia; Amar, Laurence; Meatchi, Tchao; Mantero, Franco; Cicala, Maria-Verena; Quinkler, Marcus; Fallo, Francesco; Allolio, Bruno; Bernini, Giampaolo; Maccario, Mauro; Giacchetti, Gilberta; Jeunemaitre, Xavier; Mulatero, Paolo; Reincke, Martin; Zennaro, Maria-Christina 
Titel:
Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. 
Abstract:
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs). Our aim was to investigate the prevalence of somatic mutations in these genes in unselected patients with APA (n=474), collected through the European Network for the Study of Adrenal Tumors. Correlations with clinical and biochemical parameters were first analyzed in a subset of 199 patients from a single ce...    »
 
Zeitschriftentitel:
Hypertension 
Jahr:
2014 
Band / Volume:
64 
Heft / Issue:
Seitenangaben Beitrag:
354-61 
Sprache:
eng 
Print-ISSN:
0194-911X 
TUM Einrichtung:
Institut für Humangenetik