User: Guest  Login
Document type:
journal article 
Author(s):
von Figura, Guido; Fukuda, Akihisa; Roy, Nilotpal; Liku, Muluye E; Morris Iv, John P; Kim, Grace E; Russ, Holger A; Firpo, Matthew A; Mulvihill, Sean J; Dawson, David W; Ferrer, Jorge; Mueller, William F; Busch, Anke; Hertel, Klemens J; Hebrok, Matthias 
Title:
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. 
Abstract:
Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). However, genetic features resulting in IPMN-associated PDA (IPMN-PDA) versus PanIN-associated PDA (PanIN-PDA) are largely unknown. Here we find that loss of Brg1, a core subunit of SWI/SNF chromatin remodelling complexes, cooperates with oncogenic Kras to form cystic neoplastic lesions that resemble human I...    »
 
Journal title abbreviation:
Nat Cell Biol 
Year:
2014 
Journal volume:
16 
Journal issue:
Pages contribution:
255-67 
Language:
eng 
Print-ISSN:
1465-7392 
TUM Institution:
II. Medizinische Klinik und Poliklinik