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Dokumenttyp:
journal article 
Autor(en):
von Figura, Guido; Fukuda, Akihisa; Roy, Nilotpal; Liku, Muluye E; Morris Iv, John P; Kim, Grace E; Russ, Holger A; Firpo, Matthew A; Mulvihill, Sean J; Dawson, David W; Ferrer, Jorge; Mueller, William F; Busch, Anke; Hertel, Klemens J; Hebrok, Matthias 
Titel:
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. 
Abstract:
Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). However, genetic features resulting in IPMN-associated PDA (IPMN-PDA) versus PanIN-associated PDA (PanIN-PDA) are largely unknown. Here we find that loss of Brg1, a core subunit of SWI/SNF chromatin remodelling complexes, cooperates with oncogenic Kras to form cystic neoplastic lesions that resemble human I...    »
 
Zeitschriftentitel:
Nat Cell Biol 
Jahr:
2014 
Band / Volume:
16 
Heft / Issue:
Seitenangaben Beitrag:
255-67 
Sprache:
eng 
Print-ISSN:
1465-7392 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik