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Dokumenttyp:
journal article 
Autor(en):
Derikx, Monique H, MH; Kovacs, Peter, P; Scholz, Markus, M; Masson, Emmanuelle, E; Chen, Jian-Min, JM; Ruffert, Claudia, C; Lichtner, Peter, P; Te Morsche, Rene H M, RH; Cavestro, Giulia Martina, GM; Algül, Hana, H; Berg, Thomas, T; Bödeker, Hans, H; Blüher, Matthias, M; Bruno, Marco J, MJ; Buch, Stephan, S; Bugert, Peter, P; Cichoz-Lach, Halina, H; Dabrowski, Andrzej, A; Farré, Antoni, A; Frank, Josef, J; Gasiorowska, Anita, A; Geisz, Andrea, A; Goni, Elisabetta, E; Grothaus, Johannes, J; Grütz...    »
 
Titel:
Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. 
Abstract:
Several genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1-PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2-MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4). We aimed to refine these findings in a large European cohort.We studied 3062 patients with alcohol-related CP (ACP) or NACP and 5107 controls. Also, 1559 German...    »
 
Zeitschriftentitel:
Gut 
Jahr:
2014 
Sprache:
eng 
Print-ISSN:
0017-5749 
TUM Einrichtung:
hrungsmedizin