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Dokumenttyp:
journal article 
Autor(en):
Wuensch, Tilo; Ullrich, Sina; Schulz, Stephan; Chamaillard, Mathias; Schaltenberg, Nicola; Rath, Eva; Goebel, Ulf; Sartor, R Balfour; Prager, Matthias; Büning, Carsten; Bugert, Peter; Witt, Heiko; Haller, Dirk; Daniel, Hannelore 
Titel:
Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation. 
Abstract:
PEPT1 was proposed to be expressed only in inflamed colonic tissues in which it could contribute to inflammatory bowel disease (IBD) development by transporting bacterial peptides, such as muramyl dipeptide (MDP), that activate intracellular pattern recognition receptors, such as the nucleotide-binding and oligomerization domain 2. To better define the pathological relevance of this transporter, we analyzed PEPT1 expression during intestinal inflammation and studied the susceptibility of Pept1-d...    »
 
Zeitschriftentitel:
Inflamm Bowel Dis 
Jahr:
2014 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
671-84 
Sprache:
eng 
Print-ISSN:
1078-0998 
TUM Einrichtung:
Klinik für Ernährungsmedizin