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Document type:
journal article 
Author(s):
Westphalen, C Benedikt; Asfaha, Samuel; Hayakawa, Yoku; Takemoto, Yoshihiro; Lukin, Dana J; Nuber, Andreas H; Brandtner, Anna; Setlik, Wanda; Remotti, Helen; Muley, Ashlesha; Chen, Xiaowei; May, Randal; Houchen, Courtney W; Fox, James G; Gershon, Michael D; Quante, Michael; Wang, Timothy C 
Title:
Long-lived intestinal tuft cells serve as colon cancer-initiating cells. 
Abstract:
Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has been proposed to identify quiescent and tumor growth-sustaining stem cells. DCLK1? tuft cells are increased in inflammation-induced carcinogenesis; however, the role of these cells within the gastrointestinal epithelium and their potential as cancer-initiating cells are poorly understood. Here, using a BAC-CreERT-dependent genetic lineage-tracing strategy, we determined that a subpopulation of DCLK1? cell...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2014 
Journal volume:
124 
Journal issue:
Pages contribution:
1283-95 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
II. Medizinische Klinik und Poliklinik