Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Sreekumar, Bharath K; Belinsky, Glenn S; Einwachter, Henrik; Rhim, Andrew D; Schmid, Roland; Chung, Chuhan 
Titel:
Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions. 
Abstract:
A functional vacuolar adenosine triphosphatase (v-ATPase) complex regulates canonical Wnt/?-catenin signaling. The goal of this study was to identify the distribution of the v-ATPase in human and murine models of pancreatic intraepithelial neoplasms (PanINs) and assess its role in Wnt/?-catenin signaling.We evaluated the immunolabeling pattern of the v-ATPase in human PanIN specimens and murine PanIN-1 and PanIN-2 lesions obtained from Ptf1a(Cre/+); LSL-Kras(G12D) mice. Wnt/?-catenin signaling...    »
 
Zeitschriftentitel:
Pancreas 
Jahr:
2014 
Band / Volume:
43 
Heft / Issue:
Seitenangaben Beitrag:
1256-63 
Sprache:
eng 
Print-ISSN:
0885-3177 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik