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Dokumenttyp:
journal article 
Autor(en):
Wirth, Matthias; Stojanovic, Natasa; Christian, Jan; Paul, Mariel C; Stauber, Roland H; Schmid, Roland M; Häcker, Georg; Krämer, Oliver H; Saur, Dieter; Schneider, Günter 
Titel:
MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib. 
Abstract:
The c-MYC (MYC afterward) oncogene is well known for driving numerous oncogenic programs. However, MYC can also induce apoptosis and this function of MYC warrants further clarification. We report here that a clinically relevant proteasome inhibitor significantly increases MYC protein levels and that endogenous MYC is necessary for the induction of apoptosis. This kind of MYC-induced cell death is mediated by enhanced expression of the pro-apoptotic BCL2 family members NOXA and BIM. Quantitative...    »
 
Zeitschriftentitel:
Nucleic Acids Res 
Jahr:
2014 
Band / Volume:
42 
Heft / Issue:
16 
Seitenangaben Beitrag:
10433-47 
Sprache:
eng 
Print-ISSN:
0305-1048 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik