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Dokumenttyp:
journal article 
Autor(en):
Freitag, Jenny; Heink, Sylvia; Roth, Edith; Wittmann, Jürgen; Jäck, Hans-Martin; Kamradt, Thomas 
Titel:
Towards the generation of B-cell receptor retrogenic mice. 
Abstract:
Transgenic expression of B- and T-cell receptors (BCRs and TCRs, respectively) has been a standard tool to study lymphocyte development and function in vivo. The generation of transgenic mice is time-consuming and, therefore, a faster method to study the biology of defined lymphocyte receptors in vivo would be highly welcome. Using 2A peptide-linked multicistronic retroviral vectors to transduce stem cells, TCRs can be expressed rapidly in mice of any background. We aimed at adopting this retrog...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2014 
Band / Volume:
Heft / Issue:
10 
Seitenangaben Beitrag:
e109199 
Sprache:
eng 
TUM Einrichtung:
Neurologische Klinik und Poliklinik