Comparative prognostic value of low-density lipoprotein cholesterol and C-reactive protein in patients with stable coronary artery disease treated with percutaneous coronary intervention and chronic statin therapy.

Ndrepepa, Gjin; Braun, Siegmund; Tada, Tomohisa; Guerra, Elena; Schunkert, Heribert; Laugwitz, Karl-Ludwig; Kastrati, Adnan

doi:10.1016/j.carrev.2014.02.003

journal article

Dokumenttyp:: Comparative Study; Journal Article; Article
Autor(en):: Ndrepepa, Gjin; Braun, Siegmund; Tada, Tomohisa; Guerra, Elena; Schunkert, Heribert; Laugwitz, Karl-Ludwig; Kastrati, Adnan
Titel:: Comparative prognostic value of low-density lipoprotein cholesterol and C-reactive protein in patients with stable coronary artery disease treated with percutaneous coronary intervention and chronic statin therapy.
Abstract:: The comparative prognostic value of low density lipoprotein-cholesterol (LDL-C) and C-reactive protein (CRP) in patients with stable coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) and statin therapy is poorly investigated.The study included 7595 patients with stable CAD treated with PCI. Based on a cut-off of 100mg/dl for LDL-C and 3mg/L for CRP, patients were divided into 4 groups: patients with LDL-C<=100mg/dl and CRP<=3mg/L (n=2795); patients with LDL-C>100mg/dl and CRP<=3mg/L (n=2091); patients with LDL-C<=100mg/dl and CRP>3mg/L (n=1296); and patients with LDL-C>100mg/dl and CRP>3mg/L (n=1413). Statins at discharge were prescribed in all patients. The primary outcome was 1-year all-cause mortality.One-year mortality was 2.1% (160 deaths): 1.2% (33 deaths) among patients with LDL-C <=100mg/dl and CRP<=3mg/L, 1.4% (28 deaths) among patients with LDL-C>100mg/dl and CRP<=3mg/L, 4.8% (60 deaths) among patients with LDL-C<=100mg/dl and CRP>3mg/L and 2.9% (39 deaths) among patients with LDL-C>100mg/dl and CRP>3mg/L (P<0.001). After adjustment, CRP (hazard ratio [HR]=1.64, 95% confidence interval [CI] 1.33-2.02, for 1 standard deviation increase in the logarithmic scale) but not LDL-C (HR=1.03 [0.90-1.17], for 30mg/dl increase) showed an independent association with 1-year mortality. CRP (P=0.045) but not LDL-C (P=0.294) increased the discriminatory power of multivariable model for prediction of mortality.In patients with stable CAD treated with PCI and statin therapy, CRP but not LDL-C was independently associated with increased risk of 1-year mortality.
Zeitschriftentitel:: Cardiovasc Revasc Med
Jahr:: 2014
Band / Volume:: 15
Heft / Issue:: 3
Seitenangaben Beitrag:: 131-6
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.carrev.2014.02.003
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/24630704
Print-ISSN:: 1553-8389
TUM Einrichtung:: I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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Vorkommen:

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2014

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2014