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Document type:
journal article 
Author(s):
Lehmann-Horn, Klaus; Kinzel, Silke; Feldmann, Linda; Radelfahr, Florentine; Hemmer, Bernhard; Traffehn, Sarah; Bernard, Claude C A; Stadelmann, Christine; Brück, Wolfgang; Weber, Martin S 
Title:
Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity. 
Abstract:
Clinical trials revealed that systemic administration of B-cell-depleting anti-CD20 antibodies can hold lesion formation in the early relapsing-remitting phase of multiple sclerosis (MS). Throughout the secondary-progressive (SP) course of MS, pathogenic B cells may, however, progressively replicate within the central nervous system (CNS) itself, which is largely inaccessible to systemic anti-CD20 treatment. Utilizing the murine MS model of experimental autoimmune encephalomyelitis, we show that...    »
 
Journal title abbreviation:
Annals of clinical and translational neurology 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
490-6 
Language:
eng 
Print-ISSN:
2328-9503 
TUM Institution:
Neurologische Klinik und Poliklinik