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Dokumenttyp:
journal article 
Autor(en):
Hartmann, Jana; Karl, Rosa M; Alexander, Ryan P D; Adelsberger, Helmuth; Brill, Monika S; Rühlmann, Charlotta; Ansel, Anna; Sakimura, Kenji; Baba, Yoshihiro; Kurosaki, Tomohiro; Misgeld, Thomas; Konnerth, Arthur 
Titel:
STIM1 controls neuronal Ca²? signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior. 
Abstract:
In central mammalian neurons, activation of metabotropic glutamate receptor type1 (mGluR1) evokes a complex synaptic response consisting of IP3 receptor-dependent Ca(2+) release from internal Ca(2+) stores and a slow depolarizing potential involving TRPC3 channels. It is largely unclear how mGluR1 is linked to its downstream effectors. Here, we explored the role of stromal interaction molecule 1 (STIM1) in regulating neuronal Ca(2+) signaling and mGluR1-dependent synaptic transmission. By analyz...    »
 
Zeitschriftentitel:
Neuron 
Jahr:
2014 
Band / Volume:
82 
Heft / Issue:
Seitenangaben Beitrag:
635-44 
Sprache:
eng 
Print-ISSN:
0896-6273 
TUM Einrichtung:
Institut für Neurowissenschaften; Institut für Zellbiologie des Nervensystems