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Dokumenttyp:
journal article 
Autor(en):
Kleele, Tatjana; Marinkovi?, Petar; Williams, Philip R; Stern, Sina; Weigand, Emily E; Engerer, Peter; Naumann, Ronald; Hartmann, Jana; Karl, Rosa M; Bradke, Frank; Bishop, Derron; Herms, Jochen; Konnerth, Arthur; Kerschensteiner, Martin; Godinho, Leanne; Misgeld, Thomas 
Titel:
An assay to image neuronal microtubule dynamics in mice. 
Abstract:
Microtubule dynamics in neurons play critical roles in physiology, injury and disease and determine microtubule orientation, the cell biological correlate of neurite polarization. Several microtubule binding proteins, including end-binding protein 3 (EB3), specifically bind to the growing plus tip of microtubules. In the past, fluorescently tagged end-binding proteins have revealed microtubule dynamics in vitro and in non-mammalian model organisms. Here, we devise an imaging assay based on trans...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2014 
Band / Volume:
Seitenangaben Beitrag:
4827 
Sprache:
eng 
TUM Einrichtung:
Institut für Zellbiologie des Nervensystems; Institut für Neurowissenschaften