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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Stock, Patrick; Ljaschenko, Dmitrij; Heckmann, Manfred; Dudel, Josef 
Title:
Agonists binding nicotinic receptors elicit specific channel-opening patterns at ?? and ?? sites. 
Abstract:
'Embryonic' muscle-type nicotinic acetylcholine receptor channels (nAChRs) bind ligands at interfaces of ?- and ?- or ?-subunits. ?? and ?? sites differ in affinity, but their contributions to opening the channel have remained elusive. We compared high-resolution patch clamp currents evoked by epibatidine (Ebd), carbamylcholine (CCh) and acetylcholine (ACh). Ebd binds with 75-fold higher affinity at ?? than at ?? sites, whereas CCh and ACh prefer ?? sites. Similar short (?O1), intermediate (?O2)...    »
 
Journal title abbreviation:
J Physiol 
Year:
2014 
Journal volume:
592 
Journal issue:
Pt 12 
Pages contribution:
2501-17 
Language:
eng 
Print-ISSN:
0022-3751 
TUM Institution:
Institut für Neurowissenschaften