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Dokumenttyp:
journal article 
Autor(en):
Stock, Patrick; Ljaschenko, Dmitrij; Heckmann, Manfred; Dudel, Josef 
Titel:
Agonists binding nicotinic receptors elicit specific channel-opening patterns at ?? and ?? sites. 
Abstract:
'Embryonic' muscle-type nicotinic acetylcholine receptor channels (nAChRs) bind ligands at interfaces of ?- and ?- or ?-subunits. ?? and ?? sites differ in affinity, but their contributions to opening the channel have remained elusive. We compared high-resolution patch clamp currents evoked by epibatidine (Ebd), carbamylcholine (CCh) and acetylcholine (ACh). Ebd binds with 75-fold higher affinity at ?? than at ?? sites, whereas CCh and ACh prefer ?? sites. Similar short (?O1), intermediate (?O2)...    »
 
Zeitschriftentitel:
J Physiol 
Jahr:
2014 
Band / Volume:
592 
Heft / Issue:
Pt 12 
Seitenangaben Beitrag:
2501-17 
Sprache:
eng 
Print-ISSN:
0022-3751 
TUM Einrichtung:
Institut für Neurowissenschaften