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Dokumenttyp:
journal article 
Autor(en):
Levy, Michael; Wildemann, Brigitte; Jarius, Sven; Orellano, Benjamine; Sasidharan, Saranya; Weber, Martin S; Stuve, Olaf 
Titel:
Immunopathogenesis of neuromyelitis optica. 
Abstract:
Neuromyelitis optica (NMO, Devic's syndrome) is a clinical syndrome characterized by optic neuritis and (mostly longitudinally extensive) myelitis. If untreated, NMO usually takes a relapsing course and often results in blindness and tetra- or paraparesis. The discovery of autoantibodies to aquaporin-4, the most abundant water channel in the CNS, in 70-80% of patients with NMO (termed NMO-IgG or AQP4-Ab) and subsequent investigations into the pathogenic impact of this new reactivity have led to...    »
 
Zeitschriftentitel:
Adv Immunol 
Jahr:
2014 
Band / Volume:
121 
Seitenangaben Beitrag:
213-42 
Sprache:
eng 
Print-ISSN:
0065-2776 
TUM Einrichtung:
Neurologische Klinik und Poliklinik