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Document type:
journal article 
Author(s):
Cutter, Gary R; Stüve, Olaf 
Title:
Does risk stratification decrease the risk of natalizumab-associated PML? Where is the evidence? 
Abstract:
The use of natalizumab has likely been limited by its association with progressive multifocal leukoencephalopathy (PML), an infection caused by the human polyomavirus John Cunningham (JC). Three factors were recently identified that contribute to the overall risk of natalizumab-associated PML: (1) Positive serostatus for anti-JCV antibodies, (2) prior use of immunosuppressants, and (3) duration of natalizumab therapy. This risk stratification algorithm has not led to a reduction in the incidence...    »
 
Journal title abbreviation:
Mult Scler 
Year:
2014 
Journal volume:
20 
Journal issue:
10 
Pages contribution:
1304-5 
Language:
eng 
Print-ISSN:
1352-4585 
TUM Institution:
Neurologische Klinik und Poliklinik