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Document type:
journal article 
Author(s):
Lukowski, Robert; Krieg, Thomas; Rybalkin, Sergei D; Beavo, Joseph; Hofmann, Franz 
Title:
Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond. 
Abstract:
cGMP inhibits hypertrophy, decreases fibrosis, and protects against cardiac ischemia-reperfusion (I/R) injury. Gene-targeting studies have not defined a clear role for its major downstream effector, cGMP-dependent protein kinase I (cGKI), in cardiac hypertrophy, but do implicate cGMP-cGKI signaling in fibrosis and I/R injury. No direct cGKI activators have advanced to clinical trials, whereas cardiac trials of agents that modulate cGMP via particulate or soluble guanylyl cyclases (GCs) and phosp...    »
 
Journal title abbreviation:
Trends Pharmacol Sci 
Year:
2014 
Journal volume:
35 
Journal issue:
Pages contribution:
404-13 
Language:
eng 
Print-ISSN:
0165-6147 
TUM Institution:
Institut für Pharmakologie und Toxikologie