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Document type:
journal article 
Author(s):
Langeslag, Michiel; Malsch, Philipp; Welling, Andrea; Kress, Michaela 
Title:
Reduced excitability of gp130-deficient nociceptors is associated with increased voltage-gated potassium currents and Kcna4 channel upregulation. 
Abstract:
Neuropathic pain and pain arising from local inflammation are characterized by increased release of inflammatory mediators like interleukin-6 (IL-6) by immune cells. The levels of IL-6 is increased in various painfull conditions and correlates with the severity of thermal and mechanical hypersensitivity. Deletion of the IL-6 signal transducer glycoprotein 130 (gp130) reduces inflammation associated with hypersensitivity to thermal and mechanical stimuli. In this study, we show that nociceptor-sp...    »
 
Journal title abbreviation:
Pflugers Arch 
Year:
2014 
Journal volume:
466 
Journal issue:
11 
Pages contribution:
2153-65 
Language:
eng 
Print-ISSN:
0031-6768 
TUM Institution:
Institut für Pharmakologie und Toxikologie