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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Schramm, Andrea; Schinner, Elisabeth; Huettner, Johannes P; Kees, Frieder; Tauber, Philipp; Hofmann, Franz; Schlossmann, Jens 
Title:
Function of cGMP-dependent protein kinase II in volume load-induced diuresis. 
Abstract:
Atrial natriuretic peptide (ANP)/cGMPs cause diuresis and natriuresis. Their downstream effectors beyond cGMP remain unclear. To elucidate a probable function of cGMP-dependent protein kinase II (cGKII), we investigated renal parameters in different conditions (basal, salt diets, starving, water load) using a genetically modified mouse model (cGKII-KO), but did not detect any striking differences between WT and cGKII-KO. Thus, cGKII is proposed to play only a marginal role in the adjustment of r...    »
 
Journal title abbreviation:
Pflugers Arch 
Year:
2014 
Journal volume:
466 
Journal issue:
10 
Pages contribution:
2009-18 
Language:
eng 
Print-ISSN:
0031-6768 
TUM Institution:
Institut für Pharmakologie und Toxikologie