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Document type:
journal article 
Author(s):
Shirai, Ayumi; Yamazaki, Osamu; Horita, Shoko; Nakamura, Motonobu; Satoh, Nobuhiko; Yamada, Hideomi; Suzuki, Masashi; Kudo, Akihiko; Kawakami, Hayato; Hofmann, Franz; Nishiyama, Akira; Kume, Haruki; Enomoto, Yutaka; Homma, Yukio; Seki, George 
Title:
Angiotensin II dose-dependently stimulates human renal proximal tubule transport by the nitric oxide/guanosine 3',5'-cyclic monophosphate pathway. 
Abstract:
Stimulation of renal proximal tubule (PT) transport by angiotensin II (Ang II) is critical for regulation of BP. Notably, in rats, mice, and rabbits, the regulation of PT sodium transport by Ang II is biphasic: transport is stimulated by picomolar to nanomolar concentrations of Ang II but inhibited by nanomolar to micromolar concentrations of Ang II. However, little is known about the effects of Ang II on human PT transport. By functional analysis with isolated PTs obtained from nephrectomy surg...    »
 
Journal title abbreviation:
J Am Soc Nephrol 
Year:
2014 
Journal volume:
25 
Journal issue:
Pages contribution:
1523-32 
Language:
eng 
Print-ISSN:
1046-6673 
TUM Institution:
Institut für Pharmakologie und Toxikologie