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Dokumenttyp:
journal article 
Autor(en):
Zhang, Quan; Chibalina, Margarita V; Bengtsson, Martin; Groschner, Lukas N; Ramracheya, Reshma; Rorsman, Nils J G; Leiss, Veronika; Nassar, Mohammed A; Welling, Andrea; Gribble, Fiona M; Reimann, Frank; Hofmann, Franz; Wood, John N; Ashcroft, Frances M; Rorsman, Patrik 
Titel:
Na+ current properties in islet ?- and ?-cells reflect cell-specific Scn3a and Scn9a expression. 
Abstract:
Mouse pancreatic ?- and ?-cells are equipped with voltage-gated Na(+) currents that inactivate over widely different membrane potentials (half-maximal inactivation (V0.5) at -100 mV and -50 mV in ?- and ?-cells, respectively). Single-cell PCR analyses show that both ?- and ?-cells have Nav1.3 (Scn3) and Nav1.7 (Scn9a) ? subunits, but their relative proportions differ: ?-cells principally express Nav1.7 and ?-cells Nav1.3. In ?-cells, genetically ablating Scn3a reduces the Na(+) current by 80%. I...    »
 
Zeitschriftentitel:
J Physiol 
Jahr:
2014 
Band / Volume:
592 
Heft / Issue:
Pt 21 
Seitenangaben Beitrag:
4677-96 
Sprache:
eng 
Print-ISSN:
0022-3751 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie