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Document type:
journal article 
Author(s):
Sassi, Yassine; Ahles, Andrea; Truong, Dong-Jiunn Jeffery; Baqi, Younis; Lee, Sang-Yong; Husse, Britta; Hulot, Jean-Sébastien; Foinquinos, Ariana; Thum, Thomas; Müller, Christa E; Dendorfer, Andreas; Laggerbauer, Bernhard; Engelhardt, Stefan 
Title:
Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. 
Abstract:
Acute stimulation of cardiac ?-adrenoceptors is crucial to increasing cardiac function under stress; however, sustained ?-adrenergic stimulation has been implicated in pathological myocardial remodeling and heart failure. Here, we have demonstrated that export of cAMP from cardiac myocytes is an intrinsic cardioprotective mechanism in response to cardiac stress. We report that infusion of cAMP into mice averted myocardial hypertrophy and fibrosis in a disease model of cardiac pressure overload....    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2014 
Journal volume:
124 
Journal issue:
12 
Pages contribution:
5385-97 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Institut für Pharmakologie und Toxikologie