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Dokumenttyp:
journal article 
Autor(en):
Sassi, Yassine; Ahles, Andrea; Truong, Dong-Jiunn Jeffery; Baqi, Younis; Lee, Sang-Yong; Husse, Britta; Hulot, Jean-Sébastien; Foinquinos, Ariana; Thum, Thomas; Müller, Christa E; Dendorfer, Andreas; Laggerbauer, Bernhard; Engelhardt, Stefan 
Titel:
Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. 
Abstract:
Acute stimulation of cardiac ?-adrenoceptors is crucial to increasing cardiac function under stress; however, sustained ?-adrenergic stimulation has been implicated in pathological myocardial remodeling and heart failure. Here, we have demonstrated that export of cAMP from cardiac myocytes is an intrinsic cardioprotective mechanism in response to cardiac stress. We report that infusion of cAMP into mice averted myocardial hypertrophy and fibrosis in a disease model of cardiac pressure overload....    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2014 
Band / Volume:
124 
Heft / Issue:
12 
Seitenangaben Beitrag:
5385-97 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie