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Dokumenttyp:
journal article 
Autor(en):
Ugurel, Selma; Mentzel, Thomas; Utikal, Jochen; Helmbold, Peter; Mohr, Peter; Pföhler, Claudia; Schiller, Meinhard; Hauschild, Axel; Hein, Rüdiger; Kämpgen, Eckhardt; Kellner, Ivonne; Leverkus, Martin; Becker, Jürgen C; Ströbel, Philip; Schadendorf, Dirk 
Titel:
Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up. 
Abstract:
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor. COL1A1-PDGFB gene fusion is frequent in DFSP, rendering tumor cell proliferation and survival dependent on PDGFR? (platelet-derived growth factor receptor ?) signaling. This trial investigated imatinib as neoadjuvant treatment of DFSP, including long-term follow-up.The primary endpoint of this multicenter phase II trial was response; secondary endpoints were safety, tumor relapse, and response biomarkers. Patients with advanced p...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2014 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
499-510 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie