Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Arking, Dan E; Pulit, Sara L; Crotti, Lia; van der Harst, Pim; Munroe, Patricia B; Koopmann, Tamara T; Sotoodehnia, Nona; Rossin, Elizabeth J; Morley, Michael; Wang, Xinchen; Johnson, Andrew D; Lundby, Alicia; Gudbjartsson, Daníel F; Noseworthy, Peter A; Eijgelsheim, Mark; Bradford, Yuki; Tarasov, Kirill V; Dörr, Marcus; Müller-Nurasyid, Martina; Lahtinen, Annukka M; Nolte, Ilja M; Smith, Albert Vernon; Bis, Joshua C; Isaacs, Aaron; Newhouse, Stephen J; Evans, Daniel S; Post, Wendy S; Waggott, D...    »
 
Titel:
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. 
Abstract:
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ~8-10% of QT-interval variation...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2014 
Band / Volume:
46 
Heft / Issue:
Seitenangaben Beitrag:
826-36 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
Institut für Humangenetik; Klinik und Poliklinik für Dermatologie und Allergologie